Abstract Search

ea0025p269 | Reproduction | SFEBES2011

Kisspeptin-54 injection stimulates activity of the human GnRH pulse generator in healthy women

Jayasena Channa N , Comninos Alexander N , Misra Shivani , Ali Abbara , Aniket Tavare , Donaldson Mandy , Ghatei Mohammad A , Bloom Stephen R , Dhillo Waljit S

Background: Kisspeptin is a novel hypothalamic hormone with powerful stimulatory effects on the hypothalamo-pituitarygonadal (HPG) axis. Inactivating mutations in the kisspeptin receptor lead to pubertal failure. We have previously demonstrated that injection of kisspeptin-54 stimulates LH release in healthy men and women. Recent studies in animals suggest that endogenous kisspeptin may be involved in stimulating the GnRH pulse generator. Determining whether exogenous ad...

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ea0025oc4.7 | Bone and diabetes | SFEBES2011

Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

De Silva Akila , Salem Victoria , Long Christopher J , Makwana Aidan , Newbould Rexford D , Rabiner Eugenii A , Tavare Aniket N , Ghatei Mohammed A , Bloom Stephen R , Matthews Paul M , Beaver John D , Dhillo Waljit S

The physiological post-prandial release of the gut hormones PYY and GLP-1 is implicated in triggering CNS mechanisms underlying satiety. However, the combined effects of PYY and GLP-1 on brain circuits underlying satiety in humans remain unknown.Objective: To determine changes in CNS neuronal activity following single and combined infusions of PYY and GLP-1, using blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) in human vol...

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Endocrine Abstracts

Kisspeptin-54 injection stimulates activity of the human GnRH pulse generator in healthy women

Co-administration of the gut hormones PYY and GLP-1 to human volunteers reduces food intake and brain activation in appetite centres

BiosciAbstracts